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Hydrochloric Acid → 2-Benzyl-3-dimethylaminosulphonyl-propionic acid ethyl ester

HRID 478040
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반응식

HRID 478040 반응식
[CH2:1]([O:3][C:4](=[O:18])[CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][S:7](Cl)(=[O:9])=[O:8])[CH3:2].[CH3:19][NH:20][CH3:21].Cl>C(Cl)Cl.C(O)C>[CH2:1]([O:3][C:4](=[O:18])[CH:5]([CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH2:6][S:7]([N:20]([CH3:21])[CH3:19])(=[O:9])=[O:8])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 21475177Ethyl 2-benzyl-3-chlorosulphonylpropionate

생성물 1

HCID 544525162-Benzyl-3-dimethylaminosulphonyl-propionic acid ethyl ester

시약·촉매·용매 2

HCID 702Ethanol용매HCID 6344Dichloromethane용매

실험 절차

A solution of 359 mg of 2-benzyl-3-chlorosulphonylpropionic acid ethyl ester in 2 ml of methylene chloride is cooled to -10° and 0.464 ml of a 5.6M solution of dimethylamine in ethanol is added thereto. The solution is stirred for 15 minutes at -15°, mixed with 2N HCl and extracted with methylene chloride. The extracts are washed with water, dried with magnesium sulphate and concentrated by evaporation. The residue is chromatographed on silica gel with eluant C. Rf (A)=0.43.

후처리

  1. extractionextracted with methylene chloride
  2. washThe extracts are washed with water
  3. dry with materialdried with magnesium sulphate
  4. concentrationconcentrated by evaporation
  5. customThe residue is chromatographed on silica gel with eluant C

출처 및 근거

ORD 기록
ord-3a5fbcea709b411a819f26ef6ad292f3
출처 데이터셋
uspto-grants-1989_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04889869

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