Lithium hydroxide, monohydrate → 2-(2-Thiazolinylthio)-hydrocinnamic acid

HRID 478042노트

반응식

HRID 478042 반응식
C([O:3][C:4](=[O:19])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][C:14]1[S:15][CH2:16][CH2:17][N:18]=1)C.O.[OH-].[Li+]>C1COCC1.O>[S:15]1[CH2:16][CH2:17][N:18]=[C:14]1[S:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[CH2:6][CH2:5][C:4]([OH:19])=[O:3]

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 572061812-(2-Thiazolinylthio)hydrocinnamic acid ethyl ester

생성물 1

HCID 570633422-(2-Thiazolinylthio)-hydrocinnamic acid

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

A mixture of 250 mg of 2-(2-thiazolinylthio)hydrocinnamic acid ethyl ester, 36 mg of lithium hydroxide monohydrate and 5 ml of THF/water 9:1 is stirred at room temperature for 5 days and then concentrated to dryness by evaporation. The residue is taken up in water, washed with ethyl acetate, adjusted to pH 5 with 0.5N HCl and extracted with ethyl acetate. The extracts are washed with water, dried with sodium sulphate, concentrated by evaporation and chromatographed on silica gel with eluant R. Rf (R)=0.22.

후처리

  1. concentrationconcentrated to dryness by evaporation
  2. washwashed with ethyl acetate
  3. extractionextracted with ethyl acetate
  4. washThe extracts are washed with water
  5. dry with materialdried with sodium sulphate
  6. concentrationconcentrated by evaporation
  7. customchromatographed on silica gel with eluant R

출처 및 근거

ORD 기록
ord-3f39a6c491db44bc861b222258d43e47
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889869

반응 노트

불러오는 중…