Dimethylformamide dimethyl acetal → 4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanylthiophene-2-carbonitrile
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[C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])(=[O:3])[CH3:2].[CH3:14][N:15]([CH:17](OC)OC)[CH3:16]>C(#N)C>[CH3:14][N:15]([CH3:17])[CH:16]=[CH:2][C:1]([C:4]1[C:5]([CH3:13])=[C:6]([C:11]#[N:12])[S:7][C:8]=1[S:9][CH3:10])=[O:3]참가 물질
4
실험 절차
To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.
후처리
- temperaturethe resulting mixture heated
- temperatureat reflux for 18 hours
- concentrationThe reaction was concentrated
- customthe residue triturated with diethyl ether (20 mL)
- filtrationThe suspension was filtered
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-950cf2324e5e476fbb96a1f067bfa35a
- 출처 데이터셋
- uspto-grants-2003_11
- 특허 번호
- US06642227B2
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