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Hydrochloric Acid → HCID 136388362, 화합물

HRID 478337
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HRID 478337 반응식
[C:1]([CH2:3][C:4]1[C:8]([CH3:9])=[N:7][N:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=1)#[N:2].[CH3:16][C:17]1[S:18][C:19]([C:23](N2C=CC=N2)=[O:24])=[C:20]([CH3:22])[N:21]=1.CC(C)([O-])C.[K+].Cl>O1CCCC1>[CH3:16][C:17]1[S:18][C:19]([C:23]([OH:24])=[C:3]([C:4]2[C:8]([CH3:9])=[N:7][N:6]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[N:5]=2)[C:1]#[N:2])=[C:20]([CH3:22])[N:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 5632655-Methyl-2-phenyl-2H-1,2,3-triazole-4-acetonitrileHCID 18002319HCID 18002319, 화합물HCID 23665647Potassium tert-butoxide

생성물 1

HCID 136388362HCID 136388362, 화합물수율 51.6%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

0.90 g of 4-cyanomethyl-5-methyl-2-phenyl-1,2,3-triazole and 1.04 g of 1-(2,4-dimethylthiazol-5-carbonyl)pyrazole were dissolved in tetrahydrofuran, and 1.02 g of potassium tert-butoxide was added thereto at 0° C. After stirring for 1 hour at room temperature, diluted hydrochloric acid was added to the reaction solution to make it acid. The solution was extracted with ethyl acetate, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the resulting solid was washed with isopropyl ether to obtain 0.79 g of the aimed compound. m.p.: 117-118° C.

후처리

  1. customat 0° C
  2. extractionThe solution was extracted with ethyl acetate
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure
  5. washthe resulting solid was washed with isopropyl ether

출처 및 근거

ORD 기록
ord-21fb2fc4fd894bbaaae81c6041e7cc46
출처 데이터셋
uspto-grants-2003_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06642234B1

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