Acetic Acid → 4-Phenyl-1-(4-carboxyphenyl)piperidine

HRID 478350노트

반응식

HRID 478350 반응식
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17]C(C#N)=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[C:22]([OH:25])(=[O:24])[CH3:23]>>[C:1]1([CH:7]2[CH2:8][CH2:9][N:10]([C:13]3[CH:18]=[CH:17][C:23]([C:22]([OH:25])=[O:24])=[CH:15][CH:14]=3)[CH2:11][CH2:12]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 180010564-Phenyl-1-(4-cyanophenyl)piperidine

생성물 1

HCID 180010494-Phenyl-1-(4-carboxyphenyl)piperidine

실험 절차

To 4-phenyl-1-(4-cyanophenyl)piperidine (0.39 g) are added acetic acid (10 ml) and conc. hydrochloric acid (10 ml), and the mixture is refluxed for five hours. The reaction solution is concentrated, and to the residue is added diethyl ether/methanol. The insoluble crystals are collected by filtration, and dried under reduced pressure to give 4-phenyl-1-(4-carboxyphenyl)piperidine (0.39 g) as white powder.

후처리

  1. temperaturethe mixture is refluxed for five hours
  2. concentrationThe reaction solution is concentrated
  3. additionto the residue is added diethyl ether/methanol
  4. filtrationThe insoluble crystals are collected by filtration
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-32620f07c2644768afd7313bfeea8448
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642223B2

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