참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methyl 4-(4-methylpiperazin-1-yl)benzoate | HCID 1472668 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 4-(4-Methylpiperazin-1-yl)benzoic acid hydrochloride | HCID 18562273 | — |
반응 단계
4-(4-Methyl-piperazin-1-yl)-benzoic acid methyl ester (8.5 mmol) is dissolved in 4N HCl (15 ml) and heated under reflux for 8 hours. The mixture is cooled in an ice bath to 0-4° C., diluted with 5 ml acetone and the solid material formed is filtered off, washed with acetone and dried (vacuum). A white powder with mp. >270° C., Rf=0.11 (CH2Cl2/MeOH=9:1) is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06642239B2 |
|---|
| 출처 데이터셋 | uspto-grants-2003_11 |
|---|
| ORD ID | ord-e05871aee5d34ade99a6fdea2466975f |
|---|
| 출처 메모 | uspto-grants-2003_11 |
|---|
