Ethyl benzoylacetate → 1-(3,4-Dimethylphenyl)-3-phenyl-3-pyrazolin-5-one

반응식

C(O[C:9]1C=C[C:12]([NH:15][NH2:16])=[CH:11][CH:10]=1)C1C=CC=CC=1.[C:17]([CH2:25][C:26]([O:28]CC)=O)(=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.[C:31](OCC)(=O)[CH2:32][C:33]([CH3:35])=O>>[CH3:9][C:10]1[CH:11]=[C:12]([N:15]2[C:26](=[O:28])[CH:25]=[C:17]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)[NH:16]2)[CH:31]=[CH:32][C:33]=1[CH3:35]

참가 물질

반응물 3

HCID 7170Ethyl benzoylacetate

HCID 8868Ethyl Acetoacetate

HCID 5613924-Benzyloxyphenylhydrazine

생성물 1

HCID 187564211-(3,4-Dimethylphenyl)-3-phenyl-3-pyrazolin-5-one

실험 절차

Following the procedure of Example 3b), except substituting 3,4-dimethylphenylhydrazine for 4-benzyloxyphenylhydrazine and ethyl benzoylacetate for ethyl acetoacetate, the title compound was prepared (16.0 g; 61%). MS(ES) m/z 265 [M+H].

출처 및 근거

ORD 기록: ord-9ba70887dcb1422896b214fcde8cfb46
출처 데이터셋: uspto-grants-2003_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06642265B1

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