2-Methyl-2-thiopseudourea → neomycin B gamma-guanidino butyric acid

HRID 478938

반응식

HRID 478938 반응식
[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@H:12]([OH:17])[C@@H:11]([OH:18])[C@H:10]2[NH2:19])[C@H:4]([O:20][C@@H:21]2[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([O:28][C@H:29]3[O:34][C@@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]3[NH2:39])[C@H:22]2[OH:40])[C@@H:3]([OH:41])[C@@H:2]1[NH2:42].[NH2:43][CH2:44][CH2:45][CH2:46][C:47]([OH:49])=[O:48].CO[C:52](=[NH:54])[NH2:53].CSC(=N)N>O>[CH2:1]1[C@H:6]([NH2:7])[C@@H:5]([O:8][C@@H:9]2[O:14][C@H:13]([CH2:15][NH2:16])[C@H:12]([OH:17])[C@@H:11]([OH:18])[C@H:10]2[NH2:19])[C@H:4]([O:20][C@@H:21]2[O:25][C@H:24]([CH2:26][OH:27])[C@@H:23]([O:28][C@H:29]3[O:34][C@@H:33]([CH2:35][NH2:36])[C@@H:32]([OH:37])[C@H:31]([OH:38])[C@H:30]3[NH2:39])[C@H:22]2[OH:40])[C@@H:3]([OH:41])[C@@H:2]1[NH2:42].[NH:43]([CH2:44][CH2:45][CH2:46][C:47]([OH:49])=[O:48])[C:52]([NH2:54])=[NH:53]

참가 물질

5

반응물 3

HCID 51422-Methyl-2-thiopseudoureaHCID 75544O-MethylisoureaHCID 131724201neomycin B gamma-amino butyric acid

생성물 1

HCID 178512978neomycin B gamma-guanidino butyric acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

For guanylation, the neomycin B/γ-amino butyric acid conjugate obtained in Example 9a above is treated with O-methyl isourea or S-methyl isothiourea in water at basic pH for 34 days, resulting in guanylation of the terminal amino groups. The product is purified by ion exchange chromatography, yielding the neomycin B/γ-guanidino butyric acid conjugate 17.

후처리

  1. customresulting in guanylation of the terminal amino groups
  2. customThe product is purified by ion exchange chromatography

출처 및 근거

ORD 기록
ord-c6f4edae96e8479896f6d399ccd53340
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642365B1

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