Hydrochloric Acid → 1,2-Ethanediol, 1-phenyl-, 2-methanesulfonate, (1R)-
반응식
[CH3:1][S:2]([O:5][CH2:6][C@@H:7]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[O:8]C1CCCCO1)(=[O:4])=[O:3].Cl>CO>[CH3:1][S:2]([O:5][CH2:6][C@H:7]([OH:8])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:4])=[O:3]참가 물질
4
실험 절차
Into methanol (10 ml) were added (R)-2-phenyl-2-(3,4,5,6-tetrahydro-[2H]-pyran-2-yloxy)ethyl methanesulfonate (2.0 g) and hydrochloric acid (0.07 g), and the resulting mixture was stirred at room temperature for 3 hours. The reaction mixture was neutralized, concentrated, and then ethyl acetate and water were added to the resulting residue. The organic layer was collected by layer separation, washed with a saturated aqueous sodium chloride solution and dried with anhydrous magnesium sulfate. The desiccant was filtered off and then the solvent was distilled off to obtain a colorless oily compound mentioned above (1.4 g, 97.2%).