Hydrazine hydrate (1:1) → 6-Hydrazino-5-nitroso-pyrimidine-2,4-diamine

HRID 479095노트

반응식

HRID 479095 반응식
O.[NH2:2][NH2:3].CS[C:6]1[N:11]=[C:10]([NH2:12])[N:9]=[C:8]([NH2:13])[C:7]=1[N:14]=[O:15]>CN(C=O)C>[NH:2]([C:6]1[N:11]=[C:10]([NH2:12])[N:9]=[C:8]([NH2:13])[C:7]=1[N:14]=[O:15])[NH2:3]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 180033426-(Methylsulfanyl)-5-nitrosopyrimidine-2,4-diamine

생성물 1

HCID 112522426-Hydrazino-5-nitroso-pyrimidine-2,4-diamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Hydrazine hydrate (55% solution, 14.5 mL) was added rapidly to a suspension of (12.0 g; 64.9 mmol) of 6-Methylthio-5-nitroso-pyrimidine-2,4-diamine 2 in DMF at room temperature. The mixture was allowed to stir overnight and then the bright pink mixture was filtered and the solid washed several times with DMF followed by ether and then air dried to give 9.53 g of 6-Hydrazino-5-nitroso-pyrimidine-2,4-diamine as bright pink solid.

후처리

  1. filtrationthe bright pink mixture was filtered
  2. washthe solid washed several times with DMF
  3. customair dried

출처 및 근거

ORD 기록
ord-e1e2e8955e9c4de5a6a204fa82d2df30
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06642381B2

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