Hydrochloric Acid → 2-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride

HRID 479276

반응식

HRID 479276 반응식
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)=[CH:22][CH:21]=1.[ClH:32]>C(O)(C)C.O1CCOCC1>[ClH:1].[ClH:32].[N:26]1([C:23]2[CH:22]=[CH:21][C:20]([NH:19][C:2]3[N:11]=[C:10]([NH:12][C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[C:9]4[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=4)[N:3]=3)=[CH:25][CH:24]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 3179082-chloro-N-phenylquinazolin-4-amineHCID 4135014-(Piperidin-1-yl)aniline

생성물 1

HCID 226398092-[4-(Piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 312751,4-Dioxane용매

실험 절차

A mixture of 2-chloro-4-phenylamino-quinazoline (0.18 g) and N-(4-aminophenyl)-piperidine (0.164 g) is heated for 3 min to produce a melt which is dissolved in isopropanol (4 ml). 4 N HCl in dioxane (1 ml) is added. Recrystallization from ethanol and diethylether yields 2-[4-(piperidin-1-yl)-phenylamino]-4-phenylamino-quinazoline dihydrochloride, Rf (A1) 0.64, FAB-MS: (M+H)+=396. m.p.: (decomposition).

후처리

  1. temperatureis heated for 3 min
  2. customto produce a melt which
  3. customRecrystallization from ethanol and diethylether

출처 및 근거

ORD 기록
ord-97b8d4949d2746b69a773c2f0ed92301
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06645774B1

연결된 노트

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