Potassium thiocyanate → 4-methyl-N-(2,2,2-trifluoro-1-isothiocyanatoethyl)benzamide

HRID 479472노트

반응식

HRID 479472 반응식
Cl[CH:2]([NH:7][C:8](=[O:16])[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1)[C:3]([F:6])([F:5])[F:4].[S-:17][C:18]#[N:19].[K+]>CC(C)=O>[CH3:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]([NH:7][CH:2]([N:19]=[C:18]=[S:17])[C:3]([F:6])([F:5])[F:4])=[O:16])=[CH:10][CH:11]=1

참가 물질

4

반응물 2

HCID 516872Potassium thiocyanateHCID 12150323N-(1-chloro-2,2,2-trifluoroethyl)-4-methylbenzamide

생성물 1

HCID 121503244-methyl-N-(2,2,2-trifluoro-1-isothiocyanatoethyl)benzamide수율 61.1%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A stirred solution of Example 1B (2.00 g, 8.00 mmol) in acetone (35 mL) at ambient temperature was treated with potassium thiocyanate (1.60 g, 16.0 mmol). The reaction mixture was stirred for 12 hours, concentrated, and the crude residue was purified by flash chromatography (elution with 40% ethyl acetate/hexanes) to provide 1.34 g of the desired product as an off-white solid.

후처리

  1. concentrationconcentrated
  2. customthe crude residue was purified by flash chromatography (elution with 40% ethyl acetate/hexanes)

출처 및 근거

ORD 기록
ord-ae1143b2e1d6485fa6570a5ad5d8b773
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06645968B2

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