Thiophosgene → 2-Chloro-5-isothiocyanatopyridine
반응식
[C:1](Cl)(Cl)=[S:2].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([Cl:12])=[N:10][CH:11]=1>C(Cl)(Cl)Cl>[Cl:12][C:9]1[CH:8]=[CH:7][C:6]([N:5]=[C:1]=[S:2])=[CH:11][N:10]=1참가 물질
4
실험 절차
A solution of thiophosgene (3.21 mL, 42.1 mmol) in chloroform (10 mL) was heated at reflux and treated with a solution of 5amino-2-chloropyridine (3.61 g, 28.1 mmol) in chloroform (25 mL) for 40 minutes. The solution was heated an additional 2 hours, the reaction mixture was cooled, and the solids formed were removed by filtration. Concentration of the filtrate provided 2.73 g of the desired product as a white solid.
후처리
- temperatureat reflux
- temperatureThe solution was heated an additional 2 hours
- temperaturethe reaction mixture was cooled
- customthe solids formed
- customwere removed by filtration
출처 및 근거
- ORD 기록
- ord-76ceb25cf7374bbe9df1b49db161f721
- 출처 데이터셋
- uspto-grants-2003_11
- 특허 번호
- US06645968B2
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