Hydrochloric Acid → Methyl 4-(2-aminoethoxy)benzoate

HRID 480302

반응식

HRID 480302 반응식
[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][CH2:12][NH:13]C(=O)C(C)(C)C)=[CH:6][CH:5]=1.Cl>CCO>[CH3:1][O:2][C:3](=[O:20])[C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][CH2:12][NH2:13])=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 53886966HCID 53886966, 화합물

생성물 1

HCID 14097616Methyl 4-(2-aminoethoxy)benzoate수율 108.7%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 4-[2-(2,2-dimethyl-propionylamino)-ethoxy]-benzoic acid methyl ester (350 mg) in EtOH (6 mL) at 0° C. was added concentrated HCl (3 mL). The solution was warmed to room temperature and was concentrated in vacuo to provide the hydrochloride salt of 4-(2-amino-ethoxy)-benzoic acid methyl ester (266 mg) as a white solid which was used in the next step without further purification.

후처리

  1. concentrationwas concentrated in vacuo

출처 및 근거

ORD 기록
ord-86bf8b63bc1344aebbc700c1154023bc
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649657B2

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