OC(C1C=C2C(=CC=1)C=C(C(O)=O)C=C2)C(C)CC1N=CN(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1.[OH:43][C:44]([C:72]1[CH:73]=[C:74]2[C:79](=[CH:80][CH:81]=1)[CH:78]=[C:77]([C:82](OC)=[O:83])[CH:76]=[CH:75]2)([C:48]1[N:49]=[CH:50][N:51](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:52]=1)[CH:45]([CH3:47])[CH3:46].Cl.[CH3:87][O:88][NH2:89].ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>C1COCC1.O>[OH:43][C:44]([C:72]1[CH:73]=[C:74]2[C:79](=[CH:80][CH:81]=1)[CH:78]=[C:77]([C:82]([NH:89][O:88][CH3:87])=[O:83])[CH:76]=[CH:75]2)([C:48]1[N:49]=[CH:50][NH:51][CH:52]=1)[CH:45]([CH3:47])[CH3:46]In a similar manner to that described in Example 9-(i), a crude mixture of 6-(1-hydroxy-2-methyl-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoic acid was obtained by the reaction using methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-2-naphthoate (2.0 g). To a solution of the crude mixture in THF (30 mL) was added methoxyamine hydrochloride (354 mg), 1-hydroxybenzotriazole (594 mg) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (744 mg) under ice cooling. The mixture was stirred at room temperature for 15 h, diluted with water and extracted with ethyl acetate. The extract was concentrated and purified by column chromatography (eluent; hexane:THF=1:2) followed by crystallization from hexane-ethyl acetate to give the titled compound (1.90 g) as a pale yellow powder.
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