Sodium Hydroxide → 3-(1-tert-Butoxycarbonyl-1-methylethoxy)phenylacetic Acid

HRID 480708노트

반응식

HRID 480708 반응식
C([O:4][C:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:22]=[CH:23][CH:24]=1)[O:11][C:12]([CH3:21])([CH3:20])[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[O:6])C=C.[OH-].[Na+]>CO.O1CCCC1>[C:16]([O:15][C:13]([C:12]([CH3:21])([O:11][C:10]1[CH:9]=[C:8]([CH2:7][C:5]([OH:6])=[O:4])[CH:24]=[CH:23][CH:22]=1)[CH3:20])=[O:14])([CH3:17])([CH3:18])[CH3:19]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 18766493tert-Butyl 2-[3-(Allyloxycarbonylmethyl)phenoxy]-2-methylpropionate

생성물 1

HCID 187664143-(1-tert-Butoxycarbonyl-1-methylethoxy)phenylacetic Acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

tert-Butyl 2-[3-(allyloxycarbonylmethyl)phenoxy]-2-methylpropionate (3.35 g, 10.62 mmol) was dissolved in methanol (40 mL) and tetrahydrofuran (40 mL). Subsequently, an aqueous 2M sodium hydroxide solution (40 mL) was added thereto, and the mixture was stirred for three hours at room temperature. The resultant mixture was concentrated under reduced pressure, and the resultant concentrate was acidified with 3M hydrochloric acid. The mixture was extracted with chloroform, followed by drying over sodium sulfate and concentration under reduced pressure, whereby the target compound was obtained (2.98 g, 10.12 mmol, 95.5%).

후처리

  1. concentrationThe resultant mixture was concentrated under reduced pressure
  2. concentrationthe resultant concentrate
  3. extractionThe mixture was extracted with chloroform
  4. dry with materialby drying over sodium sulfate and concentration under reduced pressure, whereby the target compound
  5. customwas obtained (2.98 g, 10.12 mmol, 95.5%)

출처 및 근거

ORD 기록
ord-63ebdbbe60e9437a88813724a30867c2
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653334B1

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