Trifluoroacetic acid → tert-Butyl 2-bromo-2-methylpropionate
반응식
[CH2:1]=[C:2]([CH3:4])[CH3:3].[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([OH:9])=[O:8].FC(F)(F)C(O)=O>C(Cl)Cl>[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([O:9][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:8]참가 물질
5
실험 절차
Isobutene is condensed into a solution of 2-bromo-2-methylpropanoic acid (10 mmol) and trifluoroacetic acid (1 mmol) in 100 mL of CH2Cl2 until the starting material is consumed, as observed by TLC. The volatile components are evaporated in vacuo, and the residue is filtered through a pad of neutral alumina using 50% ether/hexane. The filtrate is concentrated in vacuo and used without further purification.
후처리
- customis consumed
- customThe volatile components are evaporated in vacuo
- filtrationthe residue is filtered through a pad of neutral alumina using 50% ether/hexane
- concentrationThe filtrate is concentrated in vacuo
- customused without further purification
출처 및 근거
- ORD 기록
- ord-5762bebda38142938f4f6eeb9c672c4b
- 출처 데이터셋
- uspto-grants-2004_03
- 특허 번호
- US06702705B1
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