Trifluoroacetic acid → tert-Butyl 2-bromo-2-methylpropionate

HRID 48088

반응식

HRID 48088 반응식
[CH2:1]=[C:2]([CH3:4])[CH3:3].[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([OH:9])=[O:8].FC(F)(F)C(O)=O>C(Cl)Cl>[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([O:9][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:8]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 8255IsobutyleneHCID 749242-Bromo-2-methylpropanoic acid

생성물 1

HCID 90290tert-Butyl 2-bromo-2-methylpropionate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Isobutene is condensed into a solution of 2-bromo-2-methylpropanoic acid (10 mmol) and trifluoroacetic acid (1 mmol) in 100 mL of CH2Cl2 until the starting material is consumed, as observed by TLC. The volatile components are evaporated in vacuo, and the residue is filtered through a pad of neutral alumina using 50% ether/hexane. The filtrate is concentrated in vacuo and used without further purification.

후처리

  1. customis consumed
  2. customThe volatile components are evaporated in vacuo
  3. filtrationthe residue is filtered through a pad of neutral alumina using 50% ether/hexane
  4. concentrationThe filtrate is concentrated in vacuo
  5. customused without further purification

출처 및 근거

ORD 기록
ord-5762bebda38142938f4f6eeb9c672c4b
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06702705B1

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