Hydrogen Bromide → HCID 69735974, 화합물

HRID 481068노트

반응식

HRID 481068 반응식
C[O:2][C:3]([C:5]1[C:16]2[C:15]3[N:11]([CH:12]=[CH:13][N:14]=3)[CH2:10][CH2:9][C:8]=2[NH:7][CH:6]=1)=[O:4].[BrH:17]>>[BrH:17].[N:14]1[CH:13]=[CH:12][N:11]2[C:15]=1[C:16]1[C:5]([C:3]([OH:4])=[O:2])=[CH:6][NH:7][C:8]=1[CH2:9][CH2:10]2

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 20605631HCID 20605631, 화합물

생성물 1

HCID 69735974HCID 69735974, 화합물

실험 절차

A solution of 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid methyl ester (516 mg) and 48% hydrobromic acid (5 mL) is heated at 600 for 60 hours. The mixture is cooled to room temperature and concentrated in vacuo. The residue is slurried with diethyl ether and the ether is decanted off. This is repeated until no more color is visible in the ether layer. The remaining solid is dried in vacuo to give 5,6-dihydro-4H-1,3a,6-triaza-as-indacene-8-carboxylic acid hydrobromide, 350 mg, brown solid: 1H NMR(DMSO-d6) 3.17 (2H, t), 4.40 (2H, t), 7.35 (1H, d), 7.57 (1H, d), 7.63 (1H, s) 12.34 (1H, s), 12.45 (1H, s).

후처리

  1. concentrationconcentrated in vacuo
  2. customthe ether is decanted off
  3. customThe remaining solid is dried in vacuo

출처 및 근거

ORD 기록
ord-781abc4d62eb4748be48991a843cbf0c
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06653471B2

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