Water → Ergosterol, acetate

HRID 481284노트

반응식

HRID 481284 반응식
[CH3:1][C@@H:2]([C@@H:10]1[C@@:14]2([CH3:29])[CH2:15][CH2:16][C@@H:17]3[C@@:22]4([CH3:28])[CH2:23][CH2:24][C@H:25]([OH:27])[CH2:26][C:21]4=[CH:20][CH:19]=[C:18]3[C@@H:13]2[CH2:12][CH2:11]1)/[CH:3]=[CH:4]/[C@@H:5]([CH:7]([CH3:9])[CH3:8])[CH3:6].[C:30](OC(=O)C)(=[O:32])[CH3:31].O>N1C=CC=CC=1>[C:30]([O:27][C@H:25]1[CH2:24][CH2:23][C@@:22]2([CH3:28])[C:21](=[CH:20][CH:19]=[C:18]3[C@@H:17]2[CH2:16][CH2:15][C@@:14]2([CH3:29])[C@H:13]3[CH2:12][CH2:11][C@@H:10]2[C@H:2]([CH3:1])/[CH:3]=[CH:4]/[C@H:5]([CH3:6])[CH:7]([CH3:8])[CH3:9])[CH2:26]1)(=[O:32])[CH3:31]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 444679Ergosterol

생성물 1

HCID 6436903Ergosterol, acetate수율 74%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 50 gm (0.13 mol) of ergosterol (1) in 300 ml of anhydrous pyridine was added 33.3 ml (0.35 mol) of acetic anhydride. The mixture was stirred at room temperature overnight and then 600 ml of water was added. The precipitate was filtered and washed three times with 200 ml portions of acetonitrile and then air dried to yield 42.0 g (74%) of (2).

후처리

  1. filtrationThe precipitate was filtered
  2. washwashed three times with 200 ml portions of acetonitrile
  3. customair dried

출처 및 근거

ORD 기록
ord-7b12651393e34070bd6f7c7d711280e9
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789397

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