Dimethylformamide → 8-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one

HRID 481459

반응식

HRID 481459 반응식
Cl.[NH2:2][C:3]1[CH:19]=[CH:18][C:17]2[C:8]3[NH:9][C:10](=[O:16])[C:11]4[N:12]([CH:13]=[CH:14][N:15]=4)[C:7]=3[CH2:6][C:5]=2[CH:4]=1.CN(C)C=O.[F:25][C:26]1[CH:27]=[C:28]([N:32]=[C:33]=[O:34])[CH:29]=[CH:30][CH:31]=1>C(N(CC)CC)C>[F:25][C:26]1[CH:27]=[C:28]([NH:32][C:33](=[O:34])[NH:2][C:3]2[CH:19]=[CH:18][C:17]3[C:8]4[NH:9][C:10](=[O:16])[C:11]5[N:12]([CH:13]=[CH:14][N:15]=5)[C:7]=4[CH2:6][C:5]=3[CH:4]=2)[CH:29]=[CH:30][CH:31]=1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 1230643-Fluorophenyl isocyanateHCID 189754908-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride

생성물 1

HCID 190659948-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one수율 21.5%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The preparation is carried out as in Example 36 but from 1.5 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 30 ml of dimethylformamide, 0.97 g of triethylamine and 2.64 g of 3-fluorophenyl isocyanate. There is obtained 0.44 g of 8-[3-(3-fluoro-phenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]-pyrazine-4-one in the form of a light brown solid melting above 260° C. (Analysis, % calculated C: 64.00, H: 3.76, F: 5.06, N: 18.66, O: 8.52, % found C: 64.1, H: 3.4, N: 18.6).

출처 및 근거

ORD 기록
ord-998ab15439d04bcdb15fbdc56cc3707b
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789406

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