Water → 4-(1,1-Dicyanoethyl)anisole

참여 물질

역할	이름	HCID	투입량
반응물	Water	HCID 962	—
반응물	Methyl iodide	HCID 6328	—
반응물	Sodium hydride	HCID 24758	—
반응물	(4-Methoxyphenyl)malononitrile	HCID 641441	—
용매	Dimethylformamide	HCID 6228	—
생성물	4-(1,1-Dicyanoethyl)anisole	HCID 19066445	268.5%

반응 단계

To a mixture of Compound 35 (1.0 g, 6.0 mmol) and NaH (280 mg, 7.0 mmol) in DMF (12 ml) was added MeI (1.0 g, 7.0 mmol) at room temperature. After the mixture was stirred for 22 hours, the mixture was poured into H2O (30 ml), and extracted with CH2Cl2. The combined extracts were dried (Na2SO4), and concentrated to give a yellow oil (3 g), which was purified by a column chromatography on silica gel to give Compound 35 as a colorless solid (900 mg, 81%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05789423
출처 데이터셋	uspto-grants-1998_08
ORD ID	ord-1f92e4c444b74b1aa93def5842cf23b9
출처 메모	uspto-grants-1998_08