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Water → 4-(4-Acetylaminophenyl)-1,2-Dihydro-6-Methylthiophthalazine

HRID 48180
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인쇄 미리보기

반응식

HRID 48180 반응식
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([S:21][CH3:22])[CH:19]=3)[CH:14]=[N:13][N:12]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[BH3-]C#N.[Na+].O.C([O-])(O)=O.[Na+]>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([S:21][CH3:22])[CH:19]=3)[CH2:14][NH:13][N:12]=2)=[CH:9][CH:10]=1)(=[O:3])[CH3:2]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 5003444Sodium cyanoborohydrideHCID 99444901-(4-Acetylaminophenyl)-7-Methylthiophthalazine

생성물 1

HCID 129861744-(4-Acetylaminophenyl)-1,2-Dihydro-6-Methylthiophthalazine수율 74.2%

시약·촉매·용매 1

HCID 176
Acetic Acid
용매

실험 절차

To a solution of the phthalazine 7 (130 mg, 0.42 mmol) in acetic acid (7 mL) was added NaBH3CN in portions. After stirring for 15 min, water was added. The aqueous phase was neutralized by NaHCO3, and then extracted with DCM. The combined organic phase was dried over Na2SO4. Removal of the solvent afforded the product (97 mg, 74%) which can be used directly for next step.

후처리

  1. extractionextracted with DCM
  2. dry with materialThe combined organic phase was dried over Na2SO4
  3. customRemoval of the solvent

출처 및 근거

ORD 기록
ord-9a7efb84837a45f191150388858196ea
출처 데이터셋
uspto-grants-2004_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06703390B2

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