Ethanol → N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

HRID 48201

반응식

HRID 48201 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O.I[CH2:15][CH3:16].[CH3:17][CH2:18][OH:19]>>[CH2:15]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[NH:1][C:18](=[O:19])[CH3:17])[CH2:9]1)[CH3:16]

참가 물질

4

반응물 3

HCID 702EthanolHCID 6340IodoethaneHCID 690855-Nitroisoquinoline

생성물 1

HCID 10398491N-(2-ethyl-1,2,3,4-tetrahydro-5-isoquinolinyl)acetamide

실험 절차

A solution of 5-nitroisoquinoline (25 g, 0.144 mol) in 250 mL of EtOH was treated with iodoethane (26.9 g, 0.172 mol) and the resulting solution heated at reflux for 24 hours. The reaction mixture was cooled and the material which formed was collected and dried. The material obtained was converted to the title compound by the procedures described in Example 1. A white solid was obtained (4.42 g, 17%).

후처리

  1. temperaturethe resulting solution heated
  2. temperatureat reflux for 24 hours
  3. temperatureThe reaction mixture was cooled
  4. customthe material which formed
  5. customwas collected
  6. customdried
  7. customThe material obtained

출처 및 근거

ORD 기록
ord-63374dd46e7b4aceb47f36df2ff1252c
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

연결된 노트

불러오는 중…