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Hydrochloric Acid → 2-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methyl-aminothiocarbonylaminosulfonyl)thiophene

HRID 482025
노트
인쇄 미리보기

반응식

HRID 482025 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[C:7]([NH:9][CH2:10][CH2:11][C:12]1[S:13][C:14]([S:17](=[O:20])(=[O:19])[NH2:18])=[CH:15][CH:16]=1)=[O:8].C[N:25]=[C:26]=[S:27].Cl.[CH3:29]N(C=O)C>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[C:7]([NH:9][CH2:10][CH2:11][C:12]1[S:13][C:14]([S:17]([N:18]([CH3:29])[C:26]([NH2:25])=[S:27])(=[O:19])=[O:20])=[CH:15][CH:16]=1)=[O:8]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 11167Methyl isothiocyanateHCID 152886722-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoylthiophene

생성물 1

HCID 867530092-[2-(5-Chloro-2-methoxybenzoylamino)ethyl]-5-(methyl-aminothiocarbonylaminosulfonyl)thiophene

반응 조건

온도
60 °C

실험 절차

375 mg of 2-[2-(5-chloro-2-methoxybenzoylamino)ethyl]-5-sulfamoylthiophene were dissolved in 3 ml of absolute DMF together with 415 mg of K2 CO3 and 90 mg of methyl isothiocyanate, and the mixture was then stirred for 3 h at 60° C. The cooled solution was introduced into 2N HCl and the resulting precipitate was filtered off with suction. The dried residue was chromatographed on silica gel using the eluent system ethyl acetate/toluene 1:1.

후처리

  1. filtrationthe resulting precipitate was filtered off with suction
  2. customThe dried residue was chromatographed on silica gel using the eluent system ethyl acetate/toluene 1:1

출처 및 근거

ORD 기록
ord-357659a0086b4f10a5b8ee590c545277
출처 데이터셋
uspto-grants-1998_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05792788

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