5-Bromo-8-nitroisoquinoline → 5-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline

HRID 48212

반응식

HRID 48212 반응식
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]=[CH:7]2.C([BH3-])#N.[Na+]>C(O)(=O)C.O>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[C:8]2[C:3]=1[CH2:4][CH2:5][NH:6][CH2:7]2

참가 물질

5

반응물 2

HCID 8169835-Bromo-8-nitroisoquinolineHCID 5003444Sodium cyanoborohydride

생성물 1

HCID 100380655-bromo-8-nitro-1,2,3,4-tetrahydroisoquinoline

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

Alternatively, a solution of 5-bromo-8-nitroisoquinoline (1.0 g) in glacial acetic acid (30 mL) was cooled to 0° C. and, before freezing, was treated with sodium cyanoborohydride (1.10 g). The reaction mixture was warmed slowly to room temperature under nitrogen. The reaction mixture was diluted with water and basified. Organic layer extracts were chromatographed on silica gel as before.

후처리

  1. customOrganic layer extracts were chromatographed on silica gel as before

출처 및 근거

ORD 기록
ord-92c435d16a5e4d599305b982937720f7
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

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