Quinoline-5,6-diamine → 1,4-Dihydropyrido[3,2-f]quinoxaline-2,3-dione

HRID 48215노트

반응식

HRID 48215 반응식
[N:1]1[C:10]2[C:5](=[C:6]([NH2:12])[C:7]([NH2:11])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.O.[C:14](O)(=[O:18])[C:15](O)=[O:16]>Cl>[NH:12]1[C:6]2[C:5]3[CH:4]=[CH:3][CH:2]=[N:1][C:10]=3[CH:9]=[CH:8][C:7]=2[NH:11][C:15](=[O:16])[C:14]1=[O:18]

참가 물질

4

반응물 2

HCID 426874Quinoline-5,6-diamineHCID 12252961Oxalic acid dihydrate

생성물 1

HCID 103759121,4-Dihydropyrido[3,2-f]quinoxaline-2,3-dione수율 83%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of 5,6-quinolinediamine (11.3 g, 0.071 mol) and oxalic acid hydrate (17.9 g, 0.142 mol) in 200 mL 2N HCl was heated at reflux for 2 hours. The solid (12.3 g, 83% yield) was collected by filtration and washed consecutively with water and ether.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours

출처 및 근거

ORD 기록
ord-18ce3a370f5c47b09af3e24cfb90cbdf
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

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