Hydrochloric Acid → 2-Vinyl-6-methoxynaphthalene

HRID 482166

반응식

HRID 482166 반응식
Cl.[C]=O.[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH:16](C)[C:17](O)=O)[CH:10]=[CH:9]2>Cl[Pd]Cl.C1COCC1>[CH3:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH:16]=[CH2:17])[CH:10]=[CH:9]2

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 13022-(6-Methoxy-2-naphthyl)propionic acidHCID 178418416HCID 178418416, 화합물3회

생성물 1

HCID 6035352-Vinyl-6-methoxynaphthalene

시약·촉매·용매 2

HCID 24290Palladium Chloride촉매HCID 8028Tetrahydrofuran용매

실험 절차

Charged to a 1000-gallon reactor are the filtered THF-DEK-MVN solution produced in the above procedure containing 550 kg of MVN, 825 kg of DEK, and 825 kg of THF, followed by 0.3 kg of PdCl2, 0.64 kg of CuCl2, 3.1 kg of NMDP, and 200 kg of 10 wt % HCl. The reactor is then pressured to 100 psig with carbon monoxide and the reactor temperature is adjusted to 70° C. The reactor is then pressured to 360 psig with carbon monoxide and held at this pressure until the uptake of carbon monoxide is completed. The reactor is then cooled and the pressure is vented. The reaction typically takes 4-8 hours to go to completion with >95% MVN conversion and a yield of (±)-2-(6-methoxy-2-naphthyl)propionic acid of approximately 90%.

후처리

  1. additionCharged to a 1000-gallon reactor
  2. customproduced in the above procedure
  3. customis adjusted to 70° C
  4. temperatureThe reactor is then cooled
  5. customThe reaction typically takes 4-8 hours

출처 및 근거

ORD 기록
ord-cdf26f1f53654e0aa085a2e337c9c150
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05792886

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