5-Nitroisoquinoline → 5-Aminoisoquinoline

HRID 48219

반응식

HRID 48219 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O>CO.[Ni]>[CH:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([NH2:1])[C:5]=2[CH:6]=[CH:7][N:8]=1

참가 물질

4

반응물 1

HCID 690855-Nitroisoquinoline

생성물 1

HCID 707665-Aminoisoquinoline수율 98%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

5-Nitroisoquinoline (100.3 g, 0.576 mol) was dissolved in MeOH and shaken with Raney nickel (10 g) on a Parr apparatus under a H2 atmosphere (50 psi) for 21 hours. The MeOH was removed in vacuo, the residue dissolved in chloroform (150 mL), and filtered into 600 mL petroleum ether. The solid was collected by filtration. This trituration procedure was repeated several times to give 81.24 g (98%) of the desired product.

후처리

  1. customThe MeOH was removed in vacuo
  2. dissolutionthe residue dissolved in chloroform (150 mL)
  3. filtrationfiltered into 600 mL petroleum ether
  4. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-acd1c103d3db423b8f7a7621644f9507
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703391B2

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