Benzenesulfonyl chloride → Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester

HRID 482250

반응식

HRID 482250 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH:8]=1)[OH:7].C(=O)([O-])O.[Na+].[C:15]1([S:21](Cl)(=[O:23])=[O:22])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CCOCC>[OH:7][C:6]1[CH:5]=[C:4]([O:9][S:21]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:23])=[O:22])[CH:3]=[C:2]([CH3:1])[CH:8]=1

참가 물질

5

반응물 3

HCID 7369Benzenesulfonyl chlorideHCID 10436OrcinolHCID 516892Sodium Bicarbonate

생성물 1

HCID 11054545Benzenesulfonic acid 3-hydroxy-5-methylphenyl ester수율 98.4%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

24.8 g (200 mmol) 5-methyl-resorcinol, 200 ml ether, 400 ml sodium hydrogen carbonate solution and 28.2 ml (220 mmol) benzenesulfonyl chloride were stirred for 2 d at room temperature, the organic phase was separated, the aqueous phase was extracted with ether, the combined organic phases were dried over sodium sulfate, filtered, the solvent was removed in a vacuum and 52 g (quant.) benzenesulfonic acid-3-hydroxy-5-methyl-phenyl ester was obtained. Fp 108°-110° C.

후처리

  1. customthe organic phase was separated
  2. extractionthe aqueous phase was extracted with ether
  3. dry with materialthe combined organic phases were dried over sodium sulfate
  4. filtrationfiltered
  5. customthe solvent was removed in a vacuum

출처 및 근거

ORD 기록
ord-4af34506f488478795731140f6f2a309
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05795892

연결된 노트

불러오는 중…