[CH2:1]([N:5]1[C:14]2[C:13]3[CH2:15][CH2:16][CH2:17][NH:18][C:12]=3[CH:11]=[CH:10][C:9]=2[NH:8][C:7](=[O:19])[C:6]1=[O:20])[CH2:2][CH2:3][CH3:4].CN(C)C=O.ClCCl.[C:29](OC(=O)C)(=[O:31])[CH3:30]>C(N(CC)CC)C>[C:29]([N:18]1[C:12]2[CH:11]=[CH:10][C:9]3[NH:8][C:7](=[O:19])[C:6](=[O:20])[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:14]=3[C:13]=2[CH2:15][CH2:16][CH2:17]1)(=[O:31])[CH3:30]The product from Example 89 (0.14 g, 0.5 mmol) was solubilized in a minimal amount of dimethylformamide and then treated with 2 mL dichloromethane, acetic anhydride (0.15 g) and triethylamine (0.15 g). After the mixture stirred at room temperature for 18 h, it was poured onto dichloromethane/water. The aqueous layer was washed with dichloromethane and the combined organic layers over sodium sulfate, filtered and evaporated to give a dark syrup. The syrup was purified by silica gel chromatography (ethyl acetate as eluant) to give the title compound (30 mg, 19% yield).
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