Oxo [(phenylmethyl)(1,2,3,4-tetrahydro-6-nitro-5-quinolinyl)amino]acetic Acid Ethyl Ester → HCID 20633118, 화합물
반응식
C(O[C:4](=[O:28])[C:5](=[O:27])[N:6]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:7]1[C:16]([N+:17]([O-])=O)=[CH:15][CH:14]=[C:13]2[C:8]=1[CH2:9][CH2:10][CH2:11][NH:12]2)C>O1CCCC1.[Ni]>[C:21]1([CH2:20][N:6]2[C:7]3[C:8]4[CH2:9][CH2:10][CH2:11][NH:12][C:13]=4[CH:14]=[CH:15][C:16]=3[NH:17][C:4](=[O:28])[C:5]2=[O:27])[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1참가 물질
4
실험 절차
A solution of the product from Example 92 (0.67 g, 1.7 mmol) in 20 ml tetrahydrofuran was treated with Raney nickel (0.1 g) and stirred under a hydrogen atmosphere (1 atm) for 48 hours. The Raney nickel was removed with a magnet and washed with methanol. The remaining solid was collected by filtration, washed with methanol and then dissolved in 2 N HCl and filtered. The filtrate was neutralized with saturated sodium bicarbonate and the precipitate collected by filtration and dried to give the title compound (0.30 g, 57% yield) mp>300° C.