Phenol → 1-(4-chlorophenyl)-2-phenoxyethanone

HRID 482603노트

반응식

HRID 482603 반응식
C(=O)([O-])[O-].[K+].[K+].[C:7]1([OH:13])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)=[O:17]>C(C(C)=O)C>[O:13]([CH2:15][C:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=1)=[O:17])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

5

반응물 3

HCID 996PhenolHCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromide

생성물 1

HCID 14715261-(4-chlorophenyl)-2-phenoxyethanone수율 50.4%

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

To 28.4 g (213 mmole) of anhydrous potassium carbonate suspended in 100 ml of methyl ethyl ketone was added 20 g (213 mmole) of phenol and 47 g (201 mmole) of 2-bromo-4'-chloroacetophenone. The reaction mixture was refluxed for 2.5 hours, cooled, concentrated in vacuo, partitioned between diethyl ether and water, washed with dilute aqueous sodium hydroxide, washed with brine, dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo to yield 25 g of 2-phenoxy-4'-chloroacetophenone, a white solid, mp 80°-83° C.

후처리

  1. temperatureThe reaction mixture was refluxed for 2.5 hours
  2. temperaturecooled
  3. concentrationconcentrated in vacuo
  4. custompartitioned between diethyl ether and water
  5. washwashed with dilute aqueous sodium hydroxide
  6. washwashed with brine
  7. dry with materialdried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-50b1d6e6d59a4673ab86e3f631fbb60e
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05798311

반응 노트

불러오는 중…