Sulfuric acid magnesium salt (1:1) → 2-Methyl-2,3-dihydrobenzofuran-7-amine

HRID 482958노트

반응식

HRID 482958 반응식
[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:4]=2[O:3]1.[H][H].S([O-])([O-])(=O)=O.[Mg+2]>[Ni].O1CCCC1>[NH2:11][C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[CH:7]=[CH:8][CH:9]=1

참가 물질

6

반응물 3

HCID 24083Sulfuric acid magnesium salt (1:1)HCID 135358252,3-Dihydro-2-methyl-7-nitrobenzofuranHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 135358262-Methyl-2,3-dihydrobenzofuran-7-amine

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 81 g of 1B, 400 ml of tetrahydrofuran (THF) and 3 g of activated Raney nickel catalyst was shaken under 35 p.s.i.g. hydrogen pressure at room temperature for 4 hours. The resulting mixture was treated with 20 g of magnesium sulfate, filtered and the solvent was evaporated from the filtrate, to give 7-amino-2,3-dihydro-2-methylbenzofuran (1C), as an amber syrup.

후처리

  1. filtrationfiltered
  2. customthe solvent was evaporated from the filtrate

출처 및 근거

ORD 기록
ord-5e300ed198aa443a82891f599d71acb8
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04577011

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