Sodium borohydride → 3-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-one

HRID 483050노트

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HRID 483050 반응식
[CH3:1][N:2]1[CH2:8][C:6](=[O:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4].[BH4-].[Na+]>CO>[CH3:1][N:2]1[CH2:8][CH:6]([OH:7])[N:5]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[C:11]([Cl:16])[CH:10]=2)[C:3]1=[O:4]

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 130655013-(3,4-Dichlorophenyl)-1-methylimidazolidine-2,4-dione

생성물 1

HCID 133423223-(3,4-Dichlorophenyl)-4-hydroxy-1-methylimidazolidin-2-one수율 88%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
10 °C

실험 절차

A 10.4 g (0.04 mole) quantity of 1-methyl-3-(3,4-dichlorophenyl)hydantoin was suspended in 80 ml of methanol. The suspension was cooled to 10° C. and 1.5 g of sodium borohydride was added thereto with stirring. After the addition, the mixture was stirred for 30 minutes and warmed to room temperature, followed by further agitation for 2 hours. After completion of the reaction, the reaction mixture was concentrated and water was added to the residue to deposit crystals. The crystals were filtered and recrystallized from ethanol, affording 9.2 g of white crystals in 88% yield.

후처리

  1. additionAfter the addition
  2. stirringthe mixture was stirred for 30 minutes
  3. temperaturewarmed to room temperature
  4. customAfter completion of the reaction
  5. concentrationthe reaction mixture was concentrated
  6. additionwater was added to the residue to deposit crystals
  7. filtrationThe crystals were filtered
  8. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-ee842a301c4c485abcff6b956cd87ed3
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578107

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