Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydroxyquinoline-3-carbaldehyde → 3-(Hydroxymethyl)-1,2-dihydroquinolin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydroxyquinoline-3-carbaldehyde | HCID 589334 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-(Hydroxymethyl)-1,2-dihydroquinolin-2-one | HCID 2764578 | — |
반응 단계
34 Grams of 3-formylcarbostyril was suspended in 800 ml of methanol, and 7.4 g of sodium borohydride was added gradually thereto under ice-cooled condition with stirring. The reaction mixture was further stirred under ice-cooling for 3 hours. The precipitated crystals were collected by filtration and recrystallized from methanol to obtain 33.2 g of 3-hydroxymethylcarbostyril in the form of colorless prism-like crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04578381 |
| 출처 데이터셋 | uspto-grants-1986_03 |
| ORD ID | ord-45932f65586a41079688d756d742a943 |
| 출처 메모 | uspto-grants-1986_03 |