Methyl 3-aminocrotonate → HCID 11755183, 화합물

HRID 483198

반응식

HRID 483198 반응식
[Cl:1][C:2]1[C:9]([F:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.N/[C:12](/[CH3:18])=[CH:13]\[C:14]([O:16][CH3:17])=[O:15].[NH2:19]/[C:20](/[CH3:36])=[CH:21]\[C:22]([O:24][CH2:25][CH2:26][N:27]([CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[CH3:28])=[O:23]>CC(O)C>[CH3:36][C:20]1[NH:19][C:12]([CH3:18])=[C:13]([C:14]([O:16][CH3:17])=[O:15])[CH:4]([C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([F:10])[C:2]=2[Cl:1])[C:21]=1[C:22]([O:24][CH2:25][CH2:26][N:27]([CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)[CH3:28])=[O:23]

참가 물질

5

반응물 3

HCID 643918Methyl 3-aminocrotonateHCID 1252918854527-73-0HCID 149449052-Chloro-3-fluorobenzaldehyde

생성물 1

HCID 11755183HCID 11755183, 화합물수율 60.9%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).

후처리

  1. temperaturewas refluxed for 8 hours
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe residue was purified by a column chromatography on silica gel

출처 및 근거

ORD 기록
ord-5f62400733ab4d17b55942c6f710d863
출처 데이터셋
uspto-grants-1986_03
특허 번호
US04578395

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