Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 3-aminocrotonate → 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-chloro-3-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 반응물 | 2-(N-Benzyl-N-methylamino)ethyl 3-amino-2-butenoate | HCID 12529188 | — |
| 반응물 | 2-Chloro-3-fluorobenzaldehyde | HCID 14944905 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-chloro-3-fluorophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 11755183 | 60.9% |
반응 단계
A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04578395 |
| 출처 데이터셋 | uspto-grants-1986_03 |
| ORD ID | ord-5f62400733ab4d17b55942c6f710d863 |
| 출처 메모 | uspto-grants-1986_03 |