2-Mercaptobenzoic Acid → 2-Styrylsulfanylbenzoic acid

HRID 48323

반응식

HRID 48323 반응식
C(Br)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C:11]([OH:20])(=[O:19])[C:12]1[C:13](=[CH:15][CH:16]=[CH:17][CH:18]=1)[SH:14]>C(O)C.[OH-].[Na+]>[CH:2]([S:14][C:13]1[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=1[C:11]([OH:20])=[O:19])=[CH:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

참가 물질

5

반응물 2

HCID 54432-Mercaptobenzoic AcidHCID 98116Bromomethylstyrene

생성물 1

HCID 698934372-Styrylsulfanylbenzoic acid수율 102.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of 1.28 g (6.49 mmol) of cinnamyl bromide in 8 ml of ethanol at room temperature under an atmosphere of nitrogen was added a solution of 1 g (6.49 mmol) of thiosalicylic acid in 5.3 ml of 10% aqueous sodium hydroxide solution. The solution was stirred at room temperature for 16 hours and the solvent then removed under reduced pressure. The residue was dissolved in water and concentrated hydrochloric acid was added. The resultant solid was filtered off and dried. There was obtained 1.7 g of 2-styrylsulfanylbenzoic acid as a white solid, MS: m/e 270 M+.

후처리

  1. customthe solvent then removed under reduced pressure
  2. dissolutionThe residue was dissolved in water
  3. additionconcentrated hydrochloric acid was added
  4. filtrationThe resultant solid was filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-7a3900057be74659a2b64eb7fa456122
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703387B2

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