홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triphenylphosphine → (-)-4'-{2-[4-(4-Nitrobenzyl)-2,5-dioxoimidazolidinyl]ethyl}acetanilide

HRID 483372
노트
인쇄 미리보기

반응식

HRID 483372 반응식
CCOC(/N=N/C(OCC)=O)=O.[N+:13]([C:16]1[CH:29]=[CH:28][C:19]([CH2:20][CH:21]2[C:25](=[O:26])[NH:24][C:23](=[O:27])[NH:22]2)=[CH:18][CH:17]=1)([O-:15])=[O:14].O[CH2:31][CH2:32][C:33]1[CH:42]=[CH:41][C:36]([NH:37][C:38](=[O:40])[CH3:39])=[CH:35][CH:34]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>COCCOC>[N+:13]([C:16]1[CH:29]=[CH:28][C:19]([CH2:20][CH:21]2[C:25](=[O:26])[N:24]([CH2:31][CH2:32][C:33]3[CH:42]=[CH:41][C:36]([NH:37][C:38](=[O:40])[CH3:39])=[CH:35][CH:34]=3)[C:23](=[O:27])[NH:22]2)=[CH:18][CH:17]=1)([O-:15])=[O:14]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 11776TriphenylphosphineHCID 3295905N-[4-(2-hydroxyethyl)phenyl]acetamideHCID 5462977Diethyl azodicarboxylateHCID 104665795-[(4-Nitrophenyl)methyl]imidazolidine-2,4-dione

생성물 1

HCID 19752550(-)-4'-{2-[4-(4-Nitrobenzyl)-2,5-dioxoimidazolidinyl]ethyl}acetanilide수율 71.8%

시약·촉매·용매 1

HCID 8071
1,2-Dimethoxyethane
용매
2회

실험 절차

A solution of diethylazodicarboxylate (7.8 g) in DME (40 ml) was added dropwise under N2 to a stirred mixture of the product from step (a) (10.5 g), the product from step (c) (8.0 g) and triphenylphosphine (11.7 g) in DME (400 ml). When addition was complete, the mixture was stirred at room temperature for 17 hours, then evaporated in vacuo and the residue crystallised from ethanol/ether (1:4 v/v) to give the desired product as a pale yellow solid (12.7 g), [α]D25 -97.8° (c=0.50, MeOH).

후처리

  1. additionWhen addition
  2. customevaporated in vacuo
  3. customthe residue crystallised from ethanol/ether (1:4 v/v)

출처 및 근거

ORD 기록
ord-7b7f32cdc2c7499fab5cf10b83476cad
출처 데이터셋
uspto-grants-1993_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05225431

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트