Hydantoin → 3-(4-Nitrobenzyl)imidazolidine-2,4-dione
반응식
[NH:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[OH-].[Na+].[N+:10]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1)([O-:12])=[O:11]>CO>[N+:10]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17][N:4]2[C:5](=[O:6])[CH2:7][NH:1][C:2]2=[O:3])=[CH:15][CH:14]=1)([O-:12])=[O:11]참가 물질
5
실험 절차
A solution of hydantoin (5.0 g, Aldrich) in 2N aqu. NaOH (25 ml) was stirred at room temperature for 1 hour, then a solution of p-nitrobenzyl bromide (10.8 g, Aldrich) in methanol (50 ml) was added and the mixture refluxed for 16 hours. The mixture was cooled and the pale yellow precipitate filtered off, dried in vacuo, and recrystalised from ethanol to give the desired product as pale yellow crystals (6.8 g).
후처리
- temperaturethe mixture refluxed for 16 hours
- temperatureThe mixture was cooled
- filtrationthe pale yellow precipitate filtered off
- customdried in vacuo
- customrecrystalised from ethanol
출처 및 근거
- ORD 기록
- ord-86d2fe63c1234c87a9d1b4441aa934dc
- 출처 데이터셋
- uspto-grants-1993_07
- 특허 번호
- US05225431
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