Hydrochloric Acid → Diethyl benzylsuccinate

HRID 483382노트

반응식

HRID 483382 반응식
[C:1]1([CH2:7][C:8](C(OCC)=O)([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>>[C:1]1([CH2:7][CH:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

3

반응물 2

HCID 313Hydrochloric AcidHCID 563419Triethyl 3-phenyl-1,2,2-propanetricarboxylate

생성물 1

HCID 576172Diethyl benzylsuccinate수율 84.7%

실험 절차

A solution of the product from step (a) (23.6 g) in c.HCl (326 ml) was stirred under reflux for 46 hours, then cooled. The resulting precipitate was extracted with chloroform (×3) and the extracts combined, washed with 2M aqu. KOH (×2), acidified to pH 4.0 (2M aqu. HCl) and cooled. The resulting precipitate was filtered off, washed with water and dried in vacuo to give the desired product (15.7 g). The 200 MHz 1H NMR was consistent with the proposed structure.

후처리

  1. temperatureunder reflux for 46 hours
  2. temperaturecooled
  3. extractionThe resulting precipitate was extracted with chloroform (×3)
  4. washwashed with 2M aqu
  5. temperaturecooled
  6. filtrationThe resulting precipitate was filtered off
  7. washwashed with water
  8. customdried in vacuo

출처 및 근거

ORD 기록
ord-bc07f67c065949cfb8820a459ba7ce85
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225431

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