Hydrochloric Acid → 4-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

HRID 483386노트

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HRID 483386 반응식
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:16].[CH3:17]O>>[ClH:16].[NH2:10][CH:9]([CH2:8][C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:15][CH:14]=1)[C:11]([O:13][CH3:17])=[O:12]

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 137064-Nitro-3-phenyl-L-alanine

생성물 1

HCID 533959764-nitro- DL-Phenylalanine, methyl ester, monohydrochloride

실험 절차

A solution of p-nitro-L-phenylalanine (12.6 g) and c.HCl (7.5 g) in methanol (150 ml) was refluxed for 1.5 hours and the solvent then evaporated in vacuo. The residue was triturated with ether and recrystallised from SVM to give the desired product as a off-white solid, [α]25 +15.3° (c=0.55, MeOH).

후처리

  1. customthe solvent then evaporated in vacuo
  2. customThe residue was triturated with ether
  3. customrecrystallised from SVM

출처 및 근거

ORD 기록
ord-71a8162ecd834347b161bb44eb91ad7d
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05225431

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