Water → N-(2,3-Dihydro-1H-inden-2-yl)acetamide

HRID 48397

반응식

HRID 48397 반응식
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](OC(=O)C)(=[O:13])[CH3:12].O>N1C=CC=CC=1>[C:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)(=[O:13])[CH3:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 763102-Aminoindane

생성물 1

HCID 12452137N-(2,3-Dihydro-1H-inden-2-yl)acetamide수율 71.1%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

2-aminoindan (6.0 g, 45 mmol) was dissolved in dry pyridine (7 ml), to which acetic anhydride (4.5 ml, 47.3 mmol) was added dropwise while cooling in ice water. After the reaction mixture was returned to room temperature and stirred for 20 minutes, water was added. The precipitate that deposited was filtered to obtain 2-acetamidoindan (5.6 g, 32 mmol).

후처리

  1. additionwas added dropwise
  2. customwas returned to room temperature
  3. filtrationThe precipitate that deposited was filtered

출처 및 근거

ORD 기록
ord-98d057ea4c4f49e8bf8e66ae144e62ee
출처 데이터셋
uspto-grants-2004_03
특허 번호
US06703421B1

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