Triethylamine → 9-[3'-(Isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine

HRID 484087노트

반응식

HRID 484087 반응식
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[NH:6][C:7]1[C:8]2[C:13]([N:14]=[C:15]3[C:20]=1[CH:19]=[C:18]([O:21][CH3:22])[CH:17]=[CH:16]3)=[CH:12][CH:11]=[C:10]([O:23][CH3:24])[CH:9]=2.[CH:28]([N:31]=[C:32]=[O:33])([CH3:30])[CH3:29].C(N(CC)CC)C>C(Cl)Cl>[CH:28]([NH:31][C:32]([O:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:25]=[CH:26][CH:27]=1)[NH:6][C:7]1[C:8]2[C:13]([N:14]=[C:15]3[C:20]=1[CH:19]=[C:18]([O:21][CH3:22])[CH:17]=[CH:16]3)=[CH:12][CH:11]=[C:10]([O:23][CH3:24])[CH:9]=2)=[O:33])([CH3:30])[CH3:29]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 61277Isopropyl isocyanateHCID 19749149HCID 19749149, 화합물

생성물 1

HCID 197494999-[3'-(Isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine수율 84%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 9-(3'-hydroxymethylanilino)-2,7-dimethoxyacridine, (300 mg, 0.66 mmol), isopropyl isocyanate (1 ml) and triethylamine (2 ml) in methylene chloride (20 ml) is stirred at room temperature for 90 minutes, and then concentrated in vacuo. The residue is chromatographed on a silica gel column using commerical chloroform as the eluent to give the 9-[3'-(isopropylaminocarbonyloxymethyl)-anilino]-2,7-dimethoxyacridine, (246 mg, 84%) as a yellow solid, mp 148°-149° C.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe residue is chromatographed on a silica gel column

출처 및 근거

ORD 기록
ord-2c6c5ec64e9f43f29d6b28bb62d13f9f
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05229395

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