Phenyl isocyanate → HCID 15049043, 화합물

HRID 484553노트

반응식

HRID 484553 반응식
[Cl-].[C:2]([CH2:5][O:6][C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]1[NH3+:13])([OH:4])=[O:3].[C:14]1([N:20]=[C:21]=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>[OH-].[Na+]>[C:14]1([NH:20][C:21](=[O:22])[NH:13][C@@H:8]2[CH2:9][CH2:10][CH2:11][CH2:12][C@H:7]2[O:6][CH2:5][C:2]([OH:4])=[O:3])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 7672Phenyl isocyanateHCID 67747384HCID 67747384, 화합물

생성물 1

HCID 15049043HCID 15049043, 화합물수율 40%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

To a solution of trans-2-carboxymethoxy-cyclohexyl ammonium chloride (0.419 g, 2 mmoles) in 2N NaOH (10 ml), phenylisocyanate (0.476 g, 4 mmoles) was added under stirring. After 1 hour the solution was extracted with diethyl ether (10 ml) and the aqueous phase was acidified with HCl 18% to pH 3. The title compound separated in the form of white crystals, which were filtered off and dried over P2O5. Thus, there were obtained 0.23 g (40%) of the title compound, melting point 166°-168° C.

후처리

  1. extractionAfter 1 hour the solution was extracted with diethyl ether (10 ml)
  2. customThe title compound separated in the form of white crystals, which
  3. filtrationwere filtered off
  4. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-6aec0ad471b44907b25d4bb1fb1ed602
출처 데이터셋
uspto-grants-1993_07
특허 번호
US05231216

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