2-Methyl-3-butyn-2-ol → 6-Hepten-3-yn-2-ol, 2,6-dimethyl-
반응식
[CH3:1][C:2]([OH:6])([C:4]#[CH:5])[CH3:3].Cl[CH2:8][C:9]([CH3:11])=[CH2:10].C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[CH3:1][C:2]([OH:6])([C:4]#[C:5][CH2:10][C:9]([CH3:11])=[CH2:8])[CH3:3]참가 물질
5
실험 절차
The coupling reaction was conducted in the manner described in the procedure of Example VI using the following reagents: 1.00 mL (10.3 mmoles) of 2-methyl-3-butyn-2-ol, 1.10 mL (11.1 mmoles) of 3-chloro-2-methylpropene, 2.34 g (16.9 mmoles) of anhydrous potassium carbonate, 89 mg (0.90 mmole) of cuprous chloride, and 165 mg (0.72 mmole) of benzyltriethylammonium chloride. Isolation of the product in the usual manner afforded 925 mg (65%) of the named alcohol, thereby demonstrating the lack of need for a solvent in this coupling reaction.
후처리
- customThe coupling reaction
출처 및 근거
- ORD 기록
- ord-d17dfcd1bd7f4f7f934de630027e17ea
- 출처 데이터셋
- uspto-grants-1993_07
- 특허 번호
- US05231232
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