홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Pyridine → N-[3-(Hydroxymethyl)phenyl]-4-(tetradecyloxy)benzamide

HRID 484592
노트
인쇄 미리보기

반응식

HRID 484592 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].N1C=CC=CC=1.[CH2:16]([O:30][C:31]1[CH:39]=[CH:38][C:34]([C:35](Cl)=[O:36])=[CH:33][CH:32]=1)[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29].C(Cl)(Cl)Cl>C(Cl)Cl.O>[OH:6][CH2:5][C:4]1[CH:3]=[C:2]([NH:1][C:35](=[O:36])[C:34]2[CH:33]=[CH:32][C:31]([O:30][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])=[CH:39][CH:38]=2)[CH:9]=[CH:8][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 1049PyridineHCID 6212ChloroformHCID 802933-Aminobenzyl alcoholHCID 9998158Benzoyl chloride, 4-(tetradecyloxy)-

생성물 1

HCID 10003333N-[3-(Hydroxymethyl)phenyl]-4-(tetradecyloxy)benzamide수율 82.1%

시약·촉매·용매 2

HCID 962Water
용매
HCID 6344Dichloromethane용매2회

실험 절차

To a solution of 8.17 g of m-aminobenzyl alcohol and 16.14 g of pyridine in 200 ml of methylene chloride is added at 0° C. over 30 minutes a solution of 18 g of p-tetradecyloxybenzoyl chloride in 200 ml of methylene chloride. Stirring is continued for another 6 hours. An additional 400 ml of chloroform and water is added followed by warming to dissolve all the solids. The warm organic layer is separated and washed with dilute hydrochloric acid and saturated sodium bicarbonate. The warm organic layer is dried and filtered. The filtrate is diluted with an equal volume of hexane and cooled in a refrigerator overnight. The resulting solid is collected and air dried to give 18.4 g of the desired product as a white solid, m.p. 112°-115° C.

후처리

  1. temperatureby warming
  2. dissolutionto dissolve all the solids
  3. customThe warm organic layer is separated
  4. washwashed with dilute hydrochloric acid and saturated sodium bicarbonate
  5. customThe warm organic layer is dried
  6. filtrationfiltered
  7. additionThe filtrate is diluted with an equal volume of hexane
  8. temperaturecooled in a refrigerator overnight
  9. customThe resulting solid is collected
  10. customair dried

출처 및 근거

ORD 기록
ord-1d0883649c7d424994873662eac1dba4
출처 데이터셋
uspto-grants-1993_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05231182

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트