4-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine → 4-(Bis(4-fluorophenyl)methylene)piperidine

HRID 484716

반응식

HRID 484716 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:22]2[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=2)=[C:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[H][H]>CO>[F:28][C:25]1[CH:26]=[CH:27][C:22]([C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:23][CH:24]=1

참가 물질

4

반응물 2

HCID 135199654-[Bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 27244364-(Bis(4-fluorophenyl)methylene)piperidine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 1.6 parts of 4-[bis(4-fluorophenyl)methylene]-1-(phenylmethyl)piperidine and 80 parts of methanol was hydrogenated at normal pressure and at room temperature with 1 part of rhodium-on-charcoal catalyst 5%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 1.2 parts of 4-[bis(4-fluorophenyl)methylene]piperidine as a residue (intermediate 14).

후처리

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

출처 및 근거

ORD 기록
ord-f88207d3b9354acea8607188c4eb2351
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533665

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