Hydrochloric Acid → N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide

HRID 484783노트

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HRID 484783 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:3]=1[NH2:4].[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16](Cl)(=[O:18])=[O:17])=[CH:12][CH:11]=1.Cl>N1C=CC=CC=1>[C:10]1([CH3:20])[CH:15]=[CH:14][C:13]([S:16]([NH:4][C:3]2[C:5]([CH3:9])=[CH:6][CH:7]=[CH:8][C:2]=2[CH3:1])(=[O:18])=[O:17])=[CH:12][CH:11]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 68962,6-DimethylanilineHCID 73974-Toluenesulfonyl chloride

생성물 1

HCID 262999N-(2,6-dimethylphenyl)-4-methylbenzenesulfonamide수율 136.2%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 23.4 g (0.12 mole) of 2,6-dimethylaniline and 40.5 g (0.19 mole) of p-toluenesulfonyl chloride in 75 ml of pyridine was heated at reflux for three hours. The mixture was cooled and poured into vigorously stirred 2N hydrochloric acid. The crude product was recrystallized from ethanol to give 45 g of the title compound. Structure assignment was supported by the nmr spectrum and by elemental analysis.

후처리

  1. temperatureat reflux for three hours
  2. temperatureThe mixture was cooled
  3. customThe crude product was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-795c7189b36c44c7b08a9d3db755d75c
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533739

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