Hydrochloric Acid → 2-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

HRID 484786노트

반응식

HRID 484786 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1.[ClH:17]>C(O)C.[Pd]>[ClH:17].[ClH:17].[CH3:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[NH:11][C:12]1[CH2:16][CH2:15][CH2:14][N:13]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 13520142N-(2-Methyl-4-nitrophenyl)-3,4-dihydro-2H-pyrrol-5-amine

생성물 1

HCID 1317142942-[(2-Methyl-4-aminophenyl)amino]-1-pyrroline, dihydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The product compound of Example 8 was dissolved in 1.2 liter of ethanol containing 53.4 ml of concentrated hydrochloric acid and hydrogenated at 2 psi over 5% palladium on carbon. After removal of catalyst by filtration, the filtrate was concentrated in vacuo to give 85 g of the title compound. Structure assignment was supported by the nmr spectrum and by elemental analysis.

후처리

  1. customAfter removal of catalyst
  2. filtrationby filtration
  3. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-7b907801ad1e442e9344b86ae0bea55e
출처 데이터셋
uspto-grants-1985_08
특허 번호
US04533739

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